OVER-THE-COUNTER
PRODUCT COMPARISON CHART
See how LUMIFY compares to other brand name products
OVERVIEW
LUMIFY eye drops is an OTC FDA approved redness reliever to reduce redness of the eye due to minor eye irritations. LUMIFY is different to other topical redness relievers because the brimonidine mechanism of action targets veins instead of arteries, which reduces redness with a lower risk of rebound redness or loss of effectiveness over time.
LUMIFY® Redness Reliever Eye Drops
VISINE® Red Eye Hydrating Comfort Eye Drops
Clear Eyes® Redness Relief
Rohto® Optic Glow® Eye Whitening Drops
Active Ingredient
Brimonidine Tartrate 0.025%
Tetrahydrozoline HCl 0.05%
- glycerin 0.25%
- Naphazoline Hydrochloride 0.012%
- Naphazoline Hydrochloride 0.012%
- Naphazoline Hydrochloride 0.03%
- Povidone 0.5%
- Propylene glycol 0.2%
- Povidone 0.5%
- Propylene glycol 0.2%
Use
Relieves redness of the eye due to minor eye irritations
For the relief of redness of the eye due to minor eye irritations
Relieves redness of the eye due to minor eye irritations
For use as a protectant against further irritation or to relieve dryness of the eye for the temporary relief of burning and irritation due to dryness of the eye
For use as a protectant against further irritation or to relieve dryness of the eye for the temporary relief of burning and irritation due to dryness of the eye
Relieves redness of the eye due to minor eye irritations
Temporarily relieves burning and irritation due to dryness of the eye
Temporarily relieves burning and irritation due to dryness of the eye
Mechanism of Action
Highly selective a2 adrenergic receptor agonist constricts venules to reduce redness
Selective constriction of venules has the potential advantage of sustaining the availability of blood and oxygen to the surrounding tissue, which would otherwise be decreased with arteriole constriction
Selective constriction of venules has the potential advantage of sustaining the availability of blood and oxygen to the surrounding tissue, which would otherwise be decreased with arteriole constriction
Selective a1 adrenergic receptor agonist constricts both arterioles and venules to reduce redness
Constriction of both arterioles and venules has the potential to limit the availability of blood and oxygen to the surrounding tissue
Constriction of both arterioles and venules has the potential to limit the availability of blood and oxygen to the surrounding tissue
Mixed a1/a2 adrenergic receptor agonist constricts both arterioles and venules to reduce redness
Constriction of both arterioles and venules has the potential to limit the availability of blood and oxygen to the surrounding tissue
Constriction of both arterioles and venules has the potential to limit the availability of blood and oxygen to the surrounding tissue
Mixed a1/a2 adrenergic receptor agonist constricts both arterioles and venules to reduce redness
Constriction of both arterioles and venules has the potential to limit the availability of blood and oxygen to the surrounding tissue
Constriction of both arterioles and venules has the potential to limit the availability of blood and oxygen to the surrounding tissue
Advertised Onset of Action*
1 minute
NA
NA
NA
Advertised Duration of Redness Relief*
Up to 8 hours
Not stated on packaging.
Up to 12 hours of comfort
Lasts up to 8 hours
Directions*
Adults and children 5 years of age and over:
– Instill 1 drop in the affected eye(s) every 6-8 hours
– Do not use more than 4 times daily
– Remove contact lenses before use
– Wait at least 10 minutes before re-inserting contact lenses after use
– If using other ophthalmic products while using this product wait at least 5 minutes between each product
– To avoid contamination, do not touch tip of container to any surface
– Replace cap after each use
Children under 5 years of age: consult a doctor
– Instill 1 drop in the affected eye(s) every 6-8 hours
– Do not use more than 4 times daily
– Remove contact lenses before use
– Wait at least 10 minutes before re-inserting contact lenses after use
– If using other ophthalmic products while using this product wait at least 5 minutes between each product
– To avoid contamination, do not touch tip of container to any surface
– Replace cap after each use
Children under 5 years of age: consult a doctor
Adults and children 6 years of age and over: put 1 or 2 drops in the affected eye(s) up to 4 times a day
Children under 6 years of age: consult a doctor
Children under 2 years of age: do not use
Children under 6 years of age: consult a doctor
Children under 2 years of age: do not use
Instill 1 to 2 drops in the affected eye(s) up to four times daily
Put 1 or 2 drop in affected eye(s) up to 4 times daily.
To Open: Push cap down firmly and twist.
To Close: Tightly snap on cap to seal.
To Open: Push cap down firmly and twist.
To Close: Tightly snap on cap to seal.
Contact Lens Instructions*
Remove contact lenses before use
Wait at least 10 minutes before re-inserting contact lenses after use
Wait at least 10 minutes before re-inserting contact lenses after use
No information on carton
Remove contact lenses before using
Remove contact lenses before using
Warnings*
For external use only
Do not use if solution changes color or becomes cloudy
Stop use and ask a doctor if you experience eye pain, changes in vision, continued redness or irritation of the eye condition worsens or persists for more than 3 days
If pregnant or breast-feeding, ask a health professional before use.
Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.
Do not use if solution changes color or becomes cloudy
Stop use and ask a doctor if you experience eye pain, changes in vision, continued redness or irritation of the eye condition worsens or persists for more than 3 days
If pregnant or breast-feeding, ask a health professional before use.
Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.
For external use only
Ask a doctor before use if you have narrow angle glaucoma. When using this product
– pupils may become enlarged temporarily
– overuse may cause more eye redness
– remove contact lenses before using
– do not use if this solution changes color or becomes cloudy
– do not touch tip of container to any surface to avoid contamination
– replace cap after each use
Stop use and ask a doctor if
– you feel eye pain
– changes in vision occur
– redness or irritation of the eye lasts
– condition worsens or lasts more than 72 hours
If pregnant or breast-feeding, ask a health professional before use.
Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.
Ask a doctor before use if you have narrow angle glaucoma. When using this product
– pupils may become enlarged temporarily
– overuse may cause more eye redness
– remove contact lenses before using
– do not use if this solution changes color or becomes cloudy
– do not touch tip of container to any surface to avoid contamination
– replace cap after each use
Stop use and ask a doctor if
– you feel eye pain
– changes in vision occur
– redness or irritation of the eye lasts
– condition worsens or lasts more than 72 hours
If pregnant or breast-feeding, ask a health professional before use.
Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.
For external use only.
Do not use if solution changes color or becomes cloudy.
Ask a doctor before use if you have narrow angle glaucoma.
When using this product
– to avoid contamination, do not touch tip to any surface
– replace cap after using
– pupils may become temporarily enlarged
Stop use and ask a doctor if
– you experience eye pain
– you experience changes in vision
– you experience continued redness or irritation of the eye
– the condition worsens or symptoms last for more than 72 hours
Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center (1-800-222-1222) right away
Do not use if solution changes color or becomes cloudy.
Ask a doctor before use if you have narrow angle glaucoma.
When using this product
– to avoid contamination, do not touch tip to any surface
– replace cap after using
– pupils may become temporarily enlarged
Stop use and ask a doctor if
– you experience eye pain
– you experience changes in vision
– you experience continued redness or irritation of the eye
– the condition worsens or symptoms last for more than 72 hours
Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center (1-800-222-1222) right away
For external use only.
Ask a doctor before use if you have narrow angle glaucoma.
When using this product
– do not touch tip of container to any surface to avoid contamination
– replace cap after each use
– do not use if solution changes color or becomes cloudy
– over use of this product may produce increased redness of the eye
– pupils may become enlarged temporarily
Stop use and ask a doctor if
– you experience eye pain
– changes in vision occur
– redness or irritation of the eyes last
– condition worsens or lasts for more than 72 hours
Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center
Ask a doctor before use if you have narrow angle glaucoma.
When using this product
– do not touch tip of container to any surface to avoid contamination
– replace cap after each use
– do not use if solution changes color or becomes cloudy
– over use of this product may produce increased redness of the eye
– pupils may become enlarged temporarily
Stop use and ask a doctor if
– you experience eye pain
– changes in vision occur
– redness or irritation of the eyes last
– condition worsens or lasts for more than 72 hours
Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center
*As stated on packaging
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Prescription
PRODUCT COMPARISON CHART
See how LUMIFY compares to this prescription eye drop product
OVERVIEW
LUMIFY eye drops is an OTC FDA approved redness reliever to reduce redness of the eye due to minor eye irritations.
Upneeq is an FDA approved RX prescribed for Blepharoptosis.
LUMIFY® Redness Reliever Eye Drops
Upneeq
Product Category
Brimonidine Tartrate 0.025%
oxymetazoline hydrochloride ophthalmic solution 0.1%
Active Ingredient
Over the counter
FDA approved Rx
Use
Relieves redness of the eye due to minor eye irritations
UPNEEQ is indicated for the treatment of acquired blepharoptosis in adults.
Directions*
Adults and children 5 years of age and over:
– Instill 1 drop in the affected eye(s) every 6-8 hours
– Do not use more than 4 times daily
– Remove contact lenses before use
– Wait at least 10 minutes before re-inserting contact lenses after use
– If using other ophthalmic products while using this product wait at least 5 minutes between each product
– To avoid contamination, do not touch tip of container to any surface
– Replace cap after each use
– Children under 5 years of age: consult a doctor
– Instill 1 drop in the affected eye(s) every 6-8 hours
– Do not use more than 4 times daily
– Remove contact lenses before use
– Wait at least 10 minutes before re-inserting contact lenses after use
– If using other ophthalmic products while using this product wait at least 5 minutes between each product
– To avoid contamination, do not touch tip of container to any surface
– Replace cap after each use
– Children under 5 years of age: consult a doctor
Follow your prescriber's directions
Instill one drop of UPNEEQ into one or both ptotic eye(s) once daily. Discard the single patient-use container immediately after dosing.
If more than one topical ophthalmic drug is being used, the drugs should be administered at least 15 minutes between applications.
Instill one drop of UPNEEQ into one or both ptotic eye(s) once daily. Discard the single patient-use container immediately after dosing.
If more than one topical ophthalmic drug is being used, the drugs should be administered at least 15 minutes between applications.
Mechanism of action
Highly selective a2 adrenergic receptor agonist constricts venules to reduce redness
Selective constriction of venules has the potential advantage of sustaining the availability of blood and oxygen to the surrounding tissue, which would otherwise be decreased with arteriole constriction
Selective constriction of venules has the potential advantage of sustaining the availability of blood and oxygen to the surrounding tissue, which would otherwise be decreased with arteriole constriction
Oxymetazoline is an alpha adrenoceptor agonist targeting a subset of adrenoreceptors in Mueller’s muscle of the eyelid.
Onset
1 minute
~5–15 minutes
Prescription Needed
No
yes
Side Effects
LUMIFY is safe for most people when used as directed. In clinical trials, side effects were mild, temporary, and infrequent.
The most common adverse events in clinical trials included (observed in 4.0% or fewer patients):
– Changes in vision/blurriness
– Eye or eyelid redness
– Dry eyes
– Irritation
– Foreign body sensation
– Swelling
The most common adverse events in clinical trials included (observed in 4.0% or fewer patients):
– Changes in vision/blurriness
– Eye or eyelid redness
– Dry eyes
– Irritation
– Foreign body sensation
– Swelling
The most common adverse reactions with UPNEEQ (occurring in 1-5% of patients) were eye inflammation, eye redness, dry eye, blurred vision, eye pain at time of use, eye irritation, and headache
Used with Contacts
Remove contact lenses before use Wait at least 10 minutes before re-inserting contact lenses after use
Contact lenses should be removed prior to instillation of UPNEEQ and may be reinserted 15 minutes following its administration.
Key Warnings
For external use only
Do not use if solution changes color or becomes cloudy
Stop use and ask a doctor if you experience eye pain, changes in vision, continued redness or irritation of the eye condition worsens or persists for more than 3 days
If pregnant or breast-feeding, ask a health professional before use.
Keep out of reach of children.If swallowed, get medical help or contact a Poison Control Center right away.
Do not use if solution changes color or becomes cloudy
Stop use and ask a doctor if you experience eye pain, changes in vision, continued redness or irritation of the eye condition worsens or persists for more than 3 days
If pregnant or breast-feeding, ask a health professional before use.
Keep out of reach of children.If swallowed, get medical help or contact a Poison Control Center right away.
Ptosis as Presenting Sign of Serious Neurologic Disease Ptosis may be associated with neurologic or orbital diseases such as stroke and/or cerebral aneurysm, Horner syndrome, myasthenia gravis, external ophthalmoplegia, orbital infection and orbital masses. Consideration should be given to these conditions in the presence of ptosis with decreased levator muscle function and/or other neurologic signs.
Potential Impacts on Cardiovascular Disease Alpha-adrenergic agonists may impact blood pressure. UPNEEQ should be used with caution in patients with severe or unstable cardiovascular disease, orthostatic hypotension, and uncontrolled hypertension or hypotension. Advise patients with cardiovascular disease, orthostatic hypotension, and/or uncontrolled hypertension/hypotension to seek immediate medical care if their condition worsens.
Potentiation of Vascular Insufficiency UPNEEQ should be used with caution in patients with cerebral or coronary insufficiency, or Sjögren’s syndrome. Advise patients to seek immediate medical care if signs and symptoms of potentiation of vascular insufficiency develop.
Risk of Angle Closure Glaucoma UPNEEQ may increase the risk of angle closure glaucoma in patients with untreated narrow-angle glaucoma. Advise patients to seek immediate medical care if signs and symptoms of acute angle closure glaucoma develop.
Risk of Contamination Patients should not touch the tip of the single patient-use container to their eye or to any surface, in order to avoid eye injury or contamination of the solution
Potential Impacts on Cardiovascular Disease Alpha-adrenergic agonists may impact blood pressure. UPNEEQ should be used with caution in patients with severe or unstable cardiovascular disease, orthostatic hypotension, and uncontrolled hypertension or hypotension. Advise patients with cardiovascular disease, orthostatic hypotension, and/or uncontrolled hypertension/hypotension to seek immediate medical care if their condition worsens.
Potentiation of Vascular Insufficiency UPNEEQ should be used with caution in patients with cerebral or coronary insufficiency, or Sjögren’s syndrome. Advise patients to seek immediate medical care if signs and symptoms of potentiation of vascular insufficiency develop.
Risk of Angle Closure Glaucoma UPNEEQ may increase the risk of angle closure glaucoma in patients with untreated narrow-angle glaucoma. Advise patients to seek immediate medical care if signs and symptoms of acute angle closure glaucoma develop.
Risk of Contamination Patients should not touch the tip of the single patient-use container to their eye or to any surface, in order to avoid eye injury or contamination of the solution
When to seek care
Seek care if you experience eye pain, changes in vision, continued redness or irritation of the eye persists for more than 3 days
– UPNEEQ is a type of medication that may affect your blood pressure. If you have heart disease, uncontrolled high or low blood pressure, or feel faint at rest or when quickly standing up, you should call your doctor if your symptoms get worse.
– Patients with reduced blood flow to the brain or heart, or patients who experience eye or mouth dryness due to an immune system disorder (Sjögren’s syndrome), should use care when taking UPNEEQ. Call your doctor immediately if you feel your symptoms may be getting worse.
– UPNEEQ may increase the risk of eye pressure due to fluid buildup (angle-closure glaucoma) in patients with untreated narrow-angle glaucoma. Call your doctor immediately if you feel increased pressure in your eye after using UPNEEQ.
– Do not let the tip of the UPNEEQ vial touch your eye or any other surface. This can help prevent eye injury or contamination. Each UPNEEQ vial is for one-time use and should be discarded after being used
– Patients with reduced blood flow to the brain or heart, or patients who experience eye or mouth dryness due to an immune system disorder (Sjögren’s syndrome), should use care when taking UPNEEQ. Call your doctor immediately if you feel your symptoms may be getting worse.
– UPNEEQ may increase the risk of eye pressure due to fluid buildup (angle-closure glaucoma) in patients with untreated narrow-angle glaucoma. Call your doctor immediately if you feel increased pressure in your eye after using UPNEEQ.
– Do not let the tip of the UPNEEQ vial touch your eye or any other surface. This can help prevent eye injury or contamination. Each UPNEEQ vial is for one-time use and should be discarded after being used
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